Molecule discovered that makes obese people develop diabetes

The main risk factors for type 2 diabetes are obesity and a sedentary lifestyle. The biomedical community has known for many years that substances produced by fatty tissue are responsible for the link between obesity and diabetes. Chronic inflammation of the adipose tissue, which is characteristic of obese people, is a crucial stage in the development of insulin resistence and type 2 diabetes, Lluis Fajas, lead author of the study and a researcher at the Institute of Health and Medical Research (Inserm) in France, told SINC.

The results of this new study show that serum levels of a chemokine molecule called CXCL5, produced by certain adipose tissue cells, appear at much high levels in the tissues of obese people than in those of individuals with normal weight. This has helped Lluis Fajass research team to come to a biomedically relevant conclusion: The CXCL5 molecule helps cause insulin resistance and type 2 diabetes.

The most important part of this study, published in the journal Cell Metabolism, is the discovery that an experimental treatment aimed at inhibiting the action of CXCL5 can help to protect obese mice from develping type 2 diabetes. If these studies can be confirmed in humans, this treatment would represent a fundamental improvement in the quality of life of obese individuals, the researcher concludes.

Bad habits cause obesity and diabetes

According to the latest data from the Spanish Diabetes Federation (FED), almost 3.5 million people in Spain have diabetes. This illness is most common in Andalusia and Murcia, regions where the highest percentage of people who are obese and sedentary. The specialists agree on the importance of prevention. Avoiding obesity, doing daily physical exercise and giving up smoking are some of the measures that could help to cut the number of diabetes cases by a half.

The International Diabetes Federation (IDF) says that more than 190 million people worldwide currently have diabetes. This figure will rise to 330 million by 2025, due to population growth, the ageing of the population, and increasing urbanisation and sedentary lifestyles. Obesity is the main avoidable risk factor in developing type 2 diabetes. Worldwide, 1.7 billion people are already at high risk of developing a non-contagious, weight-related illness, such as type 2 diabetes.

Obesity can reduce the life expectancy of people with type 2 diabetes by up to eight years, and 80% of people diagnosed with the illness are overweight at the time they are diagnosed.

At least half of all cases of type 2 diabetes among adults could be avoided if they did not put on weight. Taking action on lifestyle, such as changing diet and taking moderate physical exercise, can reduce the risk of developing type 2 diabetes by up to 60%.

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References:

Chavey C., Lazennec G., Lagarrigue S., Clapé C., Iankova I., Teyssier J., Annicotte J. S., Schmidt J., Mataki C., Yamamoto H., Sanches R., Guma A., Stich V., Vitkova M., Jardin-Watelet B., Renard E., Strieter R., Tuthill A., Hotamisligil G. S., Vidal-Puig A., Zorzano A., Langin D. y Fajas L. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metabolism; 9(4):339-49, abril de 2009.

ARINC Offers Messaging Workshop at GHI Conference on Cost-Saving Strategies for Ground Handlers

Cost-saving strategies for today’s ground handlers will be the subject of a business messaging workshop hosted by ARINC Incorporated on November 16, 2009 at the Ground Handlers International Conference in Naples, Italy. Discussion will center on ways to obtain improved messaging services while driving down overall network costs.

Laura Petrozziello, Sales & Business Manager Aviation Solutions, ARINC EMEA, will explore many choices available to messaging customers today—including recent changes in Type B service offerings and enhancements of Type B user applications.

“As a leading network provider, ARINC has pioneered many advanced features like automatic protocol translation for ‘any-to-any’ connectivity that simplifies our customers’ business,” states Petrozziello. “We have also incorporated many customer suggestions, making our Type B messaging applications the most user-friendly available today. ARINC offers several flexible pricing plans including a flat rate option. We can often save new customers as much as 60% of their messaging costs.”

Whether ground handlers and partners use older legacy systems or new technology, ARINC’s AviNet® messaging backbone has “any-to-any” interoperability built in. Ground handling companies can pick the technology that best suits their applications, without worrying about the technology choices of their partners.

The AviNet suite of messaging solutions includes AviNet Global Partner ConnectTM for efficient Type A host-to-host messaging; AviNet Type B for IATA Type B standard store-and-forward messaging; and AviNet eXchange, an open messaging solution that allows ground handlers to use new applications with Web Services and XML, while still meeting stringent industry requirements for security and message assurance.

ARINC’s Type B access products are built on ARINC’s technologically advanced AviNet platform and deliver unsurpassed reliability and user-friendly operation. AviNet Mail makes sending Type B messages as easy as sending e-mail; AviNet Connector provides a communications protocol suite and converts user application data and messages to Type B; AviNet MQ Over the Internet bridges legacy and modern systems; AviNet Fax is a low-cost fax solution for low-volume users; and AviNet FTP uses FTP to send and receive Type B messages.

The ARINC messaging workshop for ground handlers is scheduled for Monday afternoon, November 16, from 3:30 to 4:15 p.m. at the Hilton Sorrento Palace Hotel. Information will also be available at ARINC Stand 29, along with a live AviNet demonstration. Conference registration is available at www.groundhandling.com.

ARINC Incorporated, a portfolio company of The Carlyle Group, provides communications, engineering and integration solutions for commercial, defense and government customers worldwide. Headquartered in Annapolis, Maryland with regional headquarters in London and Singapore, ARINC is ISO 9001:2008 certified.

Release: 09-136

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Source: Media Newswire

Rapid supernova could be new class of exploding star

An unusual supernova rediscovered in seven-year-old data may be the first example of a new type of exploding star, possibly from a binary star system where helium flows from one white dwarf onto another and detonates in a thermonuclear explosion.

In a paper first published online Nov. 5 in the journal Science Express, University of California, Berkeley, and Lawrence Berkeley National Laboratory (LBNL) astronomer Dovi Poznanski and his colleagues describe the outburst, dubbed SN 2002bj, and why they believe it is a new type of explosion.

This is the fastest evolving supernova we have ever seen, said Poznanski, a UC Berkeley post-doctoral fellow who recently joined LBNLs Computational Cosmology Center. It was three to four times faster than a standard supernova, basically disappearing within 20 days. Its brightness just dropped like a rock.

This rapid drop, coupled with the supernovas faintness, the strong signature of helium in the spectrum of the explosion, the absence of hydrogen, and the possible presence of vanadium – an element never previously identified in supernova spectra – points toward helium detonation on a white dwarf, the astronomers said.

We think this may well be a new physical explosion mechanism, not just a minor variation of ones already known, said co-author Alex Filippenko, UC Berkeley professor of astronomy. This supernova is qualitatively different from the complete disruption of a white dwarf, known as a Type Ia supernova, or the collapse of an iron core and rebound of the surrounding material, so-called core-collapse supernovae.

Co-author Joshua Bloom, UC Berkeley associate professor of astronomy, also views SN 2002bj as a new beast quite different from the two well-known classes of supernovae.

We have seen great diversity in those two main supernova mechanisms, but even within that diversity, observationally, there is a limited range of variation spectrally and in how events evolve in time, he said. This object (SN 2002bj) falls outside that range.

The supernova was detected in 2002 in the galaxy NGC 1821, in the constellation Lepus, by Filippenkos Katzman Automatic Imaging Telescope (KAIT) at Lick Observatory near San Jose as well as by amateur astronomers. Due to an unfortunate alignment of circumstances, the supernova was erroneously classified by the astronomical community as a common Type II supernova and filed away.

In June, Poznanski happened upon the spectrum while searching for Type II supernovae he hopes to use as distance indicators to confirm the accelerating expansion of the universe. When he carefully examined a high-quality spectrum of SN 2002bj, he realized that the supernova was not a Type II at all, but an unusual kind of supernova more akin to a Type Ia.

The spectrum had been obtained seven days after its discovery by Filippenko and Douglas Leonard, at the time a UC Berkeley graduate student, now an assistant professor of astronomy at San Diego State University, using the Keck I telescope.

Its classification was a mistake, which is understandable given the conditions of the data. But, of course, a redress of old data with fresh eyes is not usually this fruitful, Leonard said.

Pulling out follow-up images made by KAIT, Poznanski and UC Berkeley graduate student Mohan Ganeshalingam found that the brightness of SN 2002bj dropped off so rapidly that the supernova disappeared 20 days after its discovery. An image of that area of the sky taken seven days prior to its discovery showed no supernova, so it had brightened and dimmed into obscurity in less than 27 days, whereas most supernovae brighten and dim over three to four months.

Searching through thousands of supernovae spectra, Poznanski and graduate student Ryan Chornock – now a post-doctoral fellow at Harvard University – could find none that had such an awkward composition, but they did come across a theory of fast but faint supernovae that seemed to fit.

Proposed by Lars Bildsten and colleagues – Bildsten is a professor of physics at the Kavli Institute for Theoretical Physics at UC Santa Barbara – the theory involves AM Canum Venaticorum (AM CVn) binary systems, which are composed of two white dwarfs, one of which is primarily made of helium that is being slowly pulled by gravity onto its companion. White dwarfs are the remnants of stars that burned their hydrogen down to carbon and oxygen or, in some particular cases, to helium.

In a 2007 Astrophysical Journal Letters paper, Bildsten and colleagues proposed that in AM CVn systems, when enough helium has been accumulated on the surface of the primary white dwarf, an explosion will occur that can power a faint … and rapidly rising (few days) thermonuclear supernova.

Christopher Stubbs, chair of the Department of Physics at Harvard University, jokingly dubbed it a .Ia (point one A) supernova, because it is one-tenth as bright for one-tenth the time as a Type Ia supernova, and the name stuck.

Filippenko noted that this explosion is nothing like a regular Type Ia explosion because the white dwarf survives the detonation of the helium shell. In fact, it has similarities to both a nova and a supernova. Novas occur when matter – primarily hydrogen – falls onto a star and accumulates in a shell that can flare up as brief thermonuclear explosions. SN 2002bj is a super nova, generating about 1,000 times the energy of a standard nova, he said.

The explosion would have created heavy elements such as chromium, which decays to vanadium and thence to titanium. Thus, absorption lines of vanadium could be expected, Poznanski said.

Filippenko noted that the past few years have yielded a bonanza of weird supernovae.

A lot of us who have studied supernovae for several decades are amazed at the quality and quantity of data coming in recently, showing interesting new subclasses or even strange new physical classes of supernovae, he said. It whets my appetite for what else we might find out there with these large, wide-sky surveys like the Palomar Transient Factory, Dark Energy Survey and the Large Synoptic Survey Telescope. KAIT has discovered about 800 supernovae, but these new surveys will find thousands or hundreds of thousands of supernovae.

Poznanski, too, is expecting the current Palomar Transient Factory, which uses a wide-field camera to search the sky daily for new objects, to find more supernovae like SN 2002bj. The factory is a project led by Shri Kulkarni, professor of astronomy at the California Institute of Technology (Caltech), and involves many of the co-authors on the Science Express paper, including Peter Nugent, co-leader of the Computational Cosmology Center at LBNL, who runs the search for transients.

The Palomar survey will be able to find many rare objects, like SN 2002bj, by scanning huge parts of the sky and not limit itself to the big, bright and nearby galaxies, Poznanski said.

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Coauthors with Poznanski, Filippenko, Nugent, Ganeshalingam, Leonard, Chornock and Bloom are Rollin C. Thomas, a member of the Computational Cosmology Center, and Weidong Li of UC Berkeleys Department of Astronomy.

The research was funded by the National Science Foundation, the Department of Energy, the Sylvia and Jim Katzman Foundation and the TABASGO Foundation, with observational assistance from the University of California Lick Observatory and the W. M. Keck Observatory in Hawaii.